PACSIN3 Antibody, FITC conjugated

Datasheet

Code	CSB-PA892456YC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PACSIN3 Polyclonal antibody

Uniprot No.

Q9UKS6

Target Names

PACSIN3

Alternative Names

Endophilin 1 antibody; Endophilin I antibody; FLJ17861 antibody; OTTHUMP00000234262 antibody; OTTHUMP00000234263 antibody; OTTHUMP00000234264 antibody; PACN3_HUMAN antibody; Pacsin3 antibody; Protein kinase C and casein kinase substrate in neurons 3 antibody; Protein kinase C and casein kinase substrate in neurons protein 3 antibody; SDPIII antibody; SH3 domain containing protein 6511 antibody; SH3 domain-containing protein 6511 antibody; syndapin III antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3 protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

Gene References into Functions

Show that in neuroendocrine chromaffin cells fusion pore expansion and catecholamine release are limited specifically by mutation of syndapin 3. PMID: 24500282
Rigidity of wedge loop in PACSIN 3 protein is a key factor in dictating diameters of tubules PMID: 22573331
PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II PMID: 12952982
PACSIN 3 acts as an auxiliary protein of TRPV4 channel that not only affects the channel's subcellular localization but also modulates its function in a stimulus-specific manner. PMID: 18174177

Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

PACSIN family

Tissue Specificity

Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney.

Database Links

HGNC: 8572

OMIM: 606513

KEGG: hsa:29763

STRING: 9606.ENSP00000298838

UniGene: Hs.334639

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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